Rational Control of Molecular Properties Is Mandatory to Exploit the Potential of PROTACs as Oral Drugs

To obtain new oral drugs in the beyond rule of five space, PROTACs among others, molecular properties should be optimized early drug discovery. Degraders call for design strategies which focus on intramolecular interaction and chameleonicity. In parallel, tailored revalidation permeability assessment prediction methods becomes fundamental this innovative chemical space.